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Personally I never got into Mass Effect. Just not entertaining to me. Got tons of good feedback but I hated it as a game.
I've heard stellar reviews of Borderlands, but haven't played it. I would go for it just because I hate Mass Effect.
The only other game I can suggest is Darksider because its freakin awesome. One of the best games I've played in a while. Normally I'm don't keep single players, normally I beat them and go trade them for something else. Darksiders was so good I've played through twice, look to play through again and won't trade it which is why I don't have Borderlands.
if you have xbox live (or any kind of live of that matter) get borderlands hands down its just an amazing game. i got it like 4 weeks ago and i cant stop playing it.
But:
if you dont have any connection, or friends that play border lands for that matter, get mass effect 2.
they both are good games so dont be torn if you get one over the other
Do you have a bunch of friends on Live, enjoy shooters, and don't care about story? Get Borderlands.
Do you like story-focused games and RPGs with tons of depth? Get Mass Effect. (Or Dragon Age).
You should get around to playing both somewhere down the line, though. Excellent games.